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Review Article | DOI: https://doi.org/BRCA-RW-26-40

Resveratrol and Trans-Resveratrol in Respiratory Diseases: Immunobiological Mechanisms and Public Health Implications

Livia dos Santos Teodoro 1*, Lara Cristina dos Santos T 2, Gabriel Alves Borges dos Santos 1, Wanessa Maria dos San 2

1 University of Uberaba, Uberaba, Minas Gerais, Brazil

2 Institute of Health Sciences, Department of Biomedicine, Laboratory of Experimental Immunopharmacology, Federal University of Triângulo Mineiro, Minas Gerais, Brazil

*Corresponding Author: Livia dos Santos Teodoro. University of Uberaba, Uberaba, Minas Gerais, Brazil

Citation: Livia dos Santos Teodoro , Lara Cristina dos Santos Teodoro, Gabriel Alves Borges dos Santos, Wanessa Maria dos Santos (2026). Resveratrol and Trans-Resveratrol in Respiratory Diseases: Immunobiological Mechanisms and Public Health Implications, J Biomedical Research and Clinical Advancements; 3 (1) 40, DOI: BRCA-RW-26-40

Copyright: Livia dos Santos Teodoro, et al © (2026). This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 29 January 2026 | Accepted: 06 February 2026 | Published: 13 February 2026

Keywords: resveratrol; trans-resveratrol; asthma; copd; respiratory inflammation; public health; immunomodulation

Abstract

Chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), represent a significant global public health burden due to their high prevalence, morbidity, and socioeconomic impact. Persistent airway inflammation, oxidative stress, and immune dysregulation are central mechanisms underlying disease progression and exacerbations. Resveratrol and its biologically active isomer, trans-resveratrol, are naturally occurring polyphenols widely investigated for their antioxidant, anti-inflammatory, and immunomodulatory properties. This mini-review summarizes current evidence on the biological effects of resveratrol and trans-resveratrol in the respiratory system, focusing on their molecular targets, signaling pathways, and immunobiological actions relevant to asthma and COPD. Special emphasis is placed on their potential role as preventive and adjuvant strategies from a public health perspective. The available data support resveratrol as a context-dependent immunomodulator capable of attenuating chronic airway inflammation while preserving essential host defense mechanisms.

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