The study investigated the awareness of instructional materials in teaching and learning by Nurse Educators in selected nursing institutions in Imo state. Four research questions and two null hypothesis were formulated for the study. The study employed the descriptive cross-sectional design on a target population of 125 lecturers from across the six nursing institutions in Imo state. The sample size for the study was 125 Nurse Educators purposively used because the target population is a manageable one. To decide on the sample, the power analysis was employed but result was ignored because it was too small for a masters degree research. A researcher-made instrument called questionnaire was the instrument for data collection. This instrument had two sections A and B. section A demands the respondents demographic variables while section B seeks answers from the questionnaire items. The instrument was validated by two experts in measurement and evaluation of Alvan Ikoku Federal University of Education Owerri plus the researcher’s supervisor. The reliability of the instrument was determined using the test-retest method. The single quantitative method was employed for data collection. The study employed the SPSS package for mean and standard deviation statistics to answer the research questions while the regression ANOVA was used for the null hypotheses. Some of the findings were that respondents expressed they had high awareness of the instructional materials used by Nurse Educators, Recommendations were made among which are: Government should provide enough/adequate instructional materials to all the colleges of nursing in the state, those challenges affecting nurse Educators from effective utilization of available instructional materials should be squarelytackled.