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Research Article | DOI: https://doi.org/BRCA-CR-25-34

Evaluation of Some Hematological Parameters in Breast Cancer Patients Attending Oncology Clinic at American Cancer Hospital, Iho, Imo State

Amaobi Rosecollet Ngozi , Nwanjo Harrison , Edward Ukamaka , Njoku Ikechukwu Godwin , Chukwu Obasi Charles , Mbah Gertrude , Nwachukwu Uchenna C *

Department Of Medical Laboratory Science, Faculty Of Health Sciences, Imo State University, Owerri. 

*Corresponding Author: Nwachukwu Uchenna C, Department Of Medical Laboratory Science, Faculty Of Health Sciences, Imo State University, Owerri

Citation: Amaobi Rosecollet Ngozi , Nwanjo Harrison, Edward Ukamaka , Njoku Ikechukwu Godwin , Chukwu Obasi Charles et al (2025). Evaluation of Some Hematological Parameters in Breast Cancer Patients Attending Oncology Clinic at American Cancer Hospital, Iho, Imo State, J Biomedical Research and Clinical Advancements; 2(5) 34, DOI: BRCA-CR-25-34

Copyright: Nwachukwu Uchenna C, et al © (2025). This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 30 September 2025 | Accepted: 04 October 2025 | Published: 15 October 2025

Keywords: hematological parameters; breast cancer patients; oncology clinic. american cancer hospital; iho

Abstract

Breast cancer is associated with complex alterations in hematological parameters. This study aimed to evaluate selected hematological parameters in breast cancer patients attending the Oncology Clinic at American Cancer Clinic, Iho. The study population comprised seventy-five (75) histologically confirmed breast cancer patients and seventy-five (75) apparently healthy individuals without any known malignancy who served as the control group. EDTA samples were analyzed for full blood count and differential count with Sysmex XP-300 hematology autoanalyzer. Data obtained in this study was analyzed using Statistical Package for Social Sciences (SPSS) version 21. The student independent t-test and one-way ANOVA were used to compare means across groups. The results showed that the mean values of hemoglobin level was significantly decreased (p=0.001) in breast cancer patients on chemo (9.56 ± 1.39 g/dL) and newly diagnosed patients (10.05 ± 1.03 g/dL) compared to post-surgery breast cancer patients on chemo (11.45 ± 1.17 g/dL) and controls (12.71 ± 1.55 g/dL), while mean lymphocyte percentage was significantly decreased (p=0.001) in newly diagnosed patients (15.07 ± 2.83%) compared to breast cancer patients on chemo (19.45 ± 3.97%), post-surgery patients on chemo (24.31 ± 3.62%) and controls (32.93 ± 8.96%). The mean total WBC count, neutrophil, monocyte, eosinophil, basophil percentage, and neutrophil-lymphocyte ratio were significantly increased (p=0.001, p=0.001, p=0.000, p=0.000, p=0.001, p=0.000) in newly diagnosed patients (9.73 ± 2.02 ×10⁹/L, 75.72 ± 4.28%, 6.30 ± 1.22%, 3.00 ± 0.95%, 0.47 ± 0.25%, 5.20 ± 1.05) compared to those on chemo (6.36 ± 1.96 ×10⁹/L, 63.07 ± 7.88%, 5.01 ± 1.15%, 1.85 ± 0.84%, 0.33 ± 0.19%, 3.40 ± 0.94), post-surgery patients on chemo (7.17 ± 1.75 ×10⁹/L, 59.18 ± 6.18%, 5.31 ± 1.11%, 2.47 ± 0.81%, 0.32 ± 0.09%, 2.48 ± 0.42) and controls (7.14 ± 1.64 ×10⁹/L, 55.85 ± 8.63%, 4.75 ± 1.07%, 2.39 ± 0.83%, 0.33 ± 0.11%, 1.98 ± 1.20). In conclusion, breast cancer is associated with significant alterations in hematological profiles, especially in newly diagnosed patients due to immune deregulations likely linked to tumor progression and treatment response but improved with chemotherapy and surgery. 

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