Case Report | DOI: https://doi.org/CCSRR-CR-25-35
Congenital Coronary Anomaly
Abstract
The treadmill ECG stress test is commonly used as a screening test to identify myocardial ischaemia. During exercise, the physiological increase in heart rate is due to a decrease in vagal tone followed by an increase in sympathetic tone and the sufficient effort during treadmill ECG stress testing is defined as achieving 85% of the age-predicted maximal heart rate. The increase in sympathetic tone and vasodilation during exercise generally causes a rise in blood pressure.An exaggerated blood pressure response, defined as a peak systolic blood pressure of > 210 mmHg in men and > 190 mmHg in women was shown to predict the risk of hypertension in normotensive individuals, A drop in systolic blood pressure > 10 mmHg is an indication to terminate the treadmill ECG stress tests, as it could be due to myocardial ischaemia leading to left ventricular dysfunction.In addition to the evaluation of CAD, the treadmill ECG stress test is also often used to evaluate for chronotropic incompetency, in which the patient is unable to mount an adequate heart rate response to exercise, leading to symptoms such as effort-related dyspnoea and lethargy.The Bruce protocol is the most commonly used andit consists of a total of seven stages, with a gradual increment in the speed and gradient of the treadmill. Each stage lasts three minutes to allow the patient to acclimatise to the specific speed and gradient before advancing to the next stage. The MET value increases as the patient advances to higher stages of the Bruce protocol. Exercise intensity during the treadmill ECG stress test is calculated in METs, which reflect the amount of oxygen consumed per minute. 1 MET is equal to 3.5 mL/min/kg of oxygen used. Continuous ECG monitoring is carried out throughout the test and into the recovery period to assess for any changes in the ST segments due to limitation of coronary blood flow may lead to myocardial ischaemia , as well as for arrhythmia. The test is often stopped before completing Stage 7, when the patient achieves the target heart rate or is symptomatic, or when the test is positive.The duration of ST-segment depression is also important, as prolonged recovery after peak stress is consistent with a positive treadmill ECG stress test. Another finding that is highly indicative of significant CAD is the occurrence of ST-segment elevation > 1 mm (often suggesting transmural ischemia) and these patients are frequently referred urgently for coronary angiography.
A 46-year-old female developed anginal episodes during treadmill testing and further evaluation revealed a congenutal coronary anomaly.
References
-
Song, J.,K (2018) Coronary Artery Vasospasm.Korean Circulation Jourmal, Sep;48(9), 767-777.
View at Publisher | View at Google Scholar -
Rocco. M.,B., Barry, J., Campbell. S., Nabel. E., Cook. E.,F., Goldman. L., Selwyn AI (1987) Circadian variation of transient myocardial ischemia in patients with coronary artery disease. Circulation,75. 395-400.
View at Publisher | View at Google Scholar -
Mulcahy. D., Cunningham. D., Crean. P., Wright. C., Keegan. J., Quyyumi. A., Park. A., Fox. K (1988) Circadian variation of total ischemic burden and its alteration with anti-anginal agents. Lancet,1. 775-778.
View at Publisher | View at Google Scholar -
Nademanee. K., Intarachot, V., Josephson, M.,A., Singh, B.,N.(1987) Circadian variation in occurrence of transient overt and silent myocardial ischemia in chronic stable angina and comparison with Prinzmetal's angina in men. American Journal of Cardiology,60,494-498.
View at Publisher | View at Google Scholar -
Parker et al (1994) Morning Increase in Ambulatory Ischemia in Patients With Stable Coronary Artery Disease, Circulation, 89, 604-614.
View at Publisher | View at Google Scholar -
Proudfit, W.,L., Shirey, E.,K., Sones, F.,M.(1966)Selective cine coronary arteriography. Correlation with clinical findings in 1,000 patients, Circulation, 33, 901-910
View at Publisher | View at Google Scholar -
H.G. Kemp, H.,G.,R.A. Kronmal, R.,A.,R.E. Vlietstra, R.,E.,R.L. Frye, R.,L.(1986)Seven year survival of patients with normal or near normal coronary arteriograms: a CASS registry study, Journal of American College of Cardiology, 7 , 479-483
View at Publisher | View at Google Scholar -
H.G. Kemp, H.,G.(1991)Syndrome X revisitedJournal of American College of Cardiology, 17 , 507- 508
View at Publisher | View at Google Scholar -
Kaski, J.,C.(1998) Chest pain and normal coronary arteriograms: role of “microvascular spasm”, Lancet, 351, 1144-1145
View at Publisher | View at Google Scholar -
Crea, F., Lanza, G.,A.(2004) Angina pectoris and normal coronary arteries: cardiac syndrome X, Heart, 90 , 457-463
View at Publisher | View at Google Scholar -
Camici, P.,G., Marraccini, P., Lorenzoni, R., Buzzigoli G., Pecori,N., Perissinotto, A. et al (1991).Coronary hemodynamics and myocardial metabolism in patients with syndrome X: response to pacing stress, Journal of American College of Cardiology, 17, 1461-1470
View at Publisher | View at Google Scholar -
Galassi,A.,R., Crea,F., Araujo,L.,I., Lammertsma, A.,A., Pupita, G.,Yamamoto, Y. et al (1993)Comparison of regional myocardial blood flow in syndrome X and one-vessel coronary artery disease, American Joutnal of Cardiology, 72, 134-139
View at Publisher | View at Google Scholar -
Hasdai,D., Gibbons,R.,J., Holmes, D.,R., Jr., Higano, S.,T., Lerman, A.(1997)Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects, Circulation, 96, 3390-3395
View at Publisher | View at Google Scholar -
Motz,W., Vogt, M., Rabenau,O., Scheler,S,, Lückhoff,A., Strauer, B.,E. (1991)Evidence of endothelial dysfunction in coronary resistance vessels in patients with angina pectoris and normal coronary angiograms, American Journal of Cardiology, 68, 996-1003
View at Publisher | View at Google Scholar -
Takemoto,M., Sun,J., Hiroki, J., Shimokawa, H., Liao,J.,K.(2002)Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase, Circulation, 106, 57-62
View at Publisher | View at Google Scholar -
Alexander, R.,W., Griffith, G.,C (1956) Anomalies of the coronary arteries and their clinical significance. Circulation,14,800–805
View at Publisher | View at Google Scholar -
Angelini, P., Villason, S., Chan, A.,V., Diez, J.,G..(1999) Normal and anomalous coronary arteries in humans. In: Angelini P, ed. Coronary Artery Anomalies: A Comprehensive Approach. Philadelphia: Lippincott Williams & Wilkins, 27–150.
View at Publisher | View at Google Scholar -
Gräni, C,, Benz, D.,C., Steffen, D.,A., Clerc, O.,F., Schmied, C., Possner, M., et al.(2017) Outcome in middle-aged individuals with anomalous origin of the coronary artery from the opposite sinus: a matched cohort study. European Heart Journal. 38, 2009– 2016.
View at Publisher | View at Google Scholar -
Ramachandran Muthiah (2022) Episodic Ischemia on Treadmill Testing, Webinar on 12th World Congress on Healthcare, Morning star hospital, Marthandam, Kanyakumari District, India, Walsh Medical Media, Health Care: Current Reviews, February 17..
View at Publisher | View at Google Scholar -
Ramachandran Muthiah (2022) Congenital coronary anomaly , Global Summit on Cardiology and Cardiac Surgery, May 09 | Webinar, Journal of clinical & Experimental Cardiology
View at Publisher | View at Google Scholar -
Muthiah R (2011) Left circumflex coronary artery is continuing to form the right coronary artery - Angiographic imaging. Journal of Saudi Heart Association, Jul. 23(3), 161-162
View at Publisher | View at Google Scholar -
Roberts, W.,C., Shirani, J. (1992)The four subtypes of anomalous origin of the leftmain coronary artery from the right aortic sinus (or from the right coronary artery)..
View at Publisher | View at Google Scholar -
American Journal of Cardiology, 70, 119-122.
View at Publisher | View at Google Scholar -
Steffensen, T.,S., Spicer,D.,E.,(2014) Congenital coronary artery anomalies for the pathologist, Fetal and Pediatric Pathology, 33, 268-288
View at Publisher | View at Google Scholar -
Villa, A.,D.,M., Sammut, E., Nair,A., et al (2016) Coronary artery anomalies overview: the normal and the abnormal, World Journal of Radiology, 8, 537-555.
View at Publisher | View at Google Scholar -
Ogden, J.,A.(1969) Congenital anomalies of the coronary arteries, American Journal of Cardiology, 70, 474-479.
View at Publisher | View at Google Scholar -
Angelini, P.(2007) Coronary artery anomalies. An entity in search of an identity, Circulation, 115, 1296-1305
View at Publisher | View at Google Scholar -
Angelini, P.(1989) Normal and anomalous coronary arteries: definitions and classification. American Heart Journal. 117, 418–434.
View at Publisher | View at Google Scholar -
Erol, C., Koplay, M., Paksoy,Y.(2013)Evaluation of anatomy, variation and anomalies of the coronary arteries with coronary computed tomography angiography, Anatolian Journal of Cardiology, 13, 154-164
View at Publisher | View at Google Scholar -
Pérez-Pomares, J.,M., Pompa,J.,L., Franco,D., et al. (2016), and pathology ESC Working GroupCongenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology – a position statement of the development, anatomy,
View at Publisher | View at Google Scholar -
Cardiovascular Research, 109, 204-216.
View at Publisher | View at Google Scholar -
Rigatelli, G., Docali,G., Rossi, P., et al (2003).Congenital coronary artery anomalies angiographic classification revisited. International Journal of Cardiovascular Imaging, 19, 361-366
View at Publisher | View at Google Scholar -
Mirchandani,S., Phoon, C.,K.,L.(2005)Management of anomalous coronary arteries from the contralateral sinus, International Journal of Cardiology, 102, 383-389
View at Publisher | View at Google Scholar -
Brothers, J.,A., Stephens, P., Gaynor,J.,W. et al.(2008) Anomalous aortic origin of a coronary artery with an interarterial course. Should family screening be routine?Journal of American College of Cardiology, 51, 2062-2064
View at Publisher | View at Google Scholar -
Spicer, D.,E., Henderson, D.,J., Chaudhry,B., et al (2015).The anatomy and development of normal and abnormal coronary arteries,Cardiology in The Young, 25, 1493-1503
View at Publisher | View at Google Scholar -
Malagò, R., Pezzato, A., Barbiani, C.,et al (2011).Coronary artery anatomy and variants,Pediatric Radiology, 41, 1505-1515
View at Publisher | View at Google Scholar -
De la Cruz, M.,V., Moreno-Rodriguez, R., Angelini, P..(1999) Chapter 2: Ontogeny of the coronary vessels. In: Angelini P, Fairchild VD, editors. Coronary Artery Anomalies: A Comprehensive Approach. Philadelphia, PA: Lippincott Williams & Wilkins). p. 11–16.
View at Publisher | View at Google Scholar -
Thiene, G., Frescura, C., Padalino, M., Basso, C., and Rizzo, S., (2021) Coronary Arteries: Normal Anatomy With Historical Notes and Embryology of Main Stems. Frontiers in Cardiovascular. Medicine. 8, 649855.
View at Publisher | View at Google Scholar -
Bogers, A.,J., Gittenberger-de Groot, A.,C., Dubbeldam, J.,A., Huysmans, H.,A.,(1988) The inadequacy of existing theories on development of the proximal coronary arteries and their connexions with the arterial trunks. International Journal of Cardiology, 20, 117–123.
View at Publisher | View at Google Scholar -
Bogers, A.,J., Gittenberger-de Groot, A.,C., Poelmann, R.,E., Péault, B.,M., Huysmans, H.,A.,(1989) Development of the origin of the coronary arteries, a matter of ingrowth or outgrowth? Anatomy and Embryology (Berl), 180,437–441.
View at Publisher | View at Google Scholar -
Tomanek, R., Angelini, P.,(2019) Embryology of coronary arteries and anatomy/pathophysiology of coronary anomalies. A comprehensive update. International Journal of Cardiology,. 281, 28–34.
View at Publisher | View at Google Scholar -
Eralp. I., Lie-Venema, H., DeRuiter, M.,C., van den Akker, N.,M.,S., Bogers, A.,J.,J.,C., Mentink, M.,M.,T., et al (2005). Coronary artery and orifice development is associated with proper timing of epicardial outgrowth and correlated Fas-ligand-associated apoptosis patterns. Circulation Research. 96, 526–534
View at Publisher | View at Google Scholar -
Mu, H., Ohashi, R., Lin, P., Yao, Q., Chen, C..(2005) Cellular and molecular mechanisms of coronary vessel development. Vascular Medicine, 10, 37–44.
View at Publisher | View at Google Scholar -
Lie-Venema, H., Gittenberger-de Groot, A.,C., Van Empel, L.,J., Boot, M.,J., Kerkdijk, H., De Kant, E., et al (2003). Ets-1 and Ets-2 transcription factors are essential for normal coronary and myocardial development in chicken embryos. Circulation Research, 92, 749–756.
View at Publisher | View at Google Scholar -
Van den Akker, N.,M., Caolo, V., Wisse. L.,J., Peters, P.,P., Poelmann, R.,E., Carmeliet, P., et al (2008). Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling. Cardiovascular Research, 78, 366–375.
View at Publisher | View at Google Scholar -
Lavine, K.,J., Ornitz, D.,M., (2009) Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature. Circulation Research, 104, 159–169.
View at Publisher | View at Google Scholar -
Räsänen, M, Sultan, I, Paech J, Hemanthakumar, K.,A., Yu, W., He, L., Tang, J., et al (2021). VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration,. Circulation, 5,143,1,65-77..
View at Publisher | View at Google Scholar -
Gittenberger-de Groot. A.,C., Vrancken Peeters, M.,P., Bergwerff, M., Mentink, M.,M., Poelmann. R.,E.. (2000) Epicardial outgrowth inhibition leads to compensatory mesothelial outflow tract collar and abnormal cardiac septation and coronary formation. Circulation Research, 87, 969–971.
View at Publisher | View at Google Scholar -
Guadix,J,A.,Ruiz-Villalba, A.,Lettice, L., Velecela, V.,Muñoz-Chápuli, R., Hastie, N.,D., Pérez-Pomares, J.,M. Martínez-Estrada,O.,M., (2011).Wt1 controls retinoic acidsignalling in embryonic epicardium through transcriptional activation of Raldh2, Development, 138, 1093–1097
View at Publisher | View at Google Scholar -
DelMonte,G..Casanova,J.,C.,Guadix,J.,A.,MacGrogan,D.,Burch,J.,B.,E.Pérez-Pomares,J.,M.,de la Pompa, J.,L.,(2011) Differential Notch signaling in the epicardium is required for cardiac inflow development and coronary vessel morphogenesis, Circulation Research, 108, 824–836
View at Publisher | View at Google Scholar -
Grieskamp, T., Rudat, C., Lüdtke, T.,H.,W. ,Norden ,J., Kispert, A.,(2011).Notch signaling regulates smooth muscle differentiation of epicardium-derived cells,Circulation Research, 108, 813–823.
View at Publisher | View at Google Scholar -
You, L., Lin. F. Lee, C.,T. Demayo, F.,J.(2005) Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity, Nature, 435, 98,–104
View at Publisher | View at Google Scholar -
Tomanek, R.,J. Ishii, Y. Holifield, J.,S. Sjogren, C.,L., Hansen, H.,K., Mikawa, T.,(2006)VEGF family members regulate myocardial tubulogenesis and coronary artery formation in the embryo, Circulation Research , 98, 947–953.
View at Publisher | View at Google Scholar -
Lavine, K.,J., White, A.,C.,Park, C., Smith, C.,S. Choi, K., Long, F., Hui,C.,Ornitz, D.,M., (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development, Genes &Development, 20, 1651–1666.
View at Publisher | View at Google Scholar -
Wu,B., Zhang, Z., Lui, W., Chen, X., Wang, Y., Chamberlain, A., Moreno-Rodriguez,R.,A., Markwald, R.,R., O'Rourke, B.,P., Sharp,D.,J., Zheng, D., Lenz, J., Baldwin, H.,S.,Chang,C.,P., Zhou,B., (2012) Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling, Cell, 151, 1083-1096
View at Publisher | View at Google Scholar -
Red-Horse, K., Ueno, H., Weissman, I.,L., Krasnow, M.,(2010) Coronary arteries form by developmental reprogramming of venous cells, Nature, 464, 549- 553.
View at Publisher | View at Google Scholar -
Katz,T.,C., Singh,M.,K., Degenhardt,K., Rivera-Feliciano, J.,Johnson,R., Epstein,J., Tabin, C.(2012) Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells, Developmental Cell, 22, 639 –650.
View at Publisher | View at Google Scholar -
Ivins,S., Chappell, J., Vernay,B., Suntharalingham,J., Martineau, A., Mohun,T.,J.,Scambler, P.,J.(2015) The CXCL12/CXCR4 axis plays a critical role in coronary artery development, Developmental Cell, 33, 455–468
View at Publisher | View at Google Scholar -
Chiu,I.,S., Anderson,R.,H.,(2012) Can we better understand the known variations in coronary arterial anatomy?Annals of Thoracic Surgery, 94, 1751–1760
View at Publisher | View at Google Scholar -
Wessels,A., Pérez-Pomares,J.,M.(2004) The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells,The anatomical record. Discoveries in molecular, cellular, and evolutionary biology.276, 43 -57.
View at Publisher | View at Google Scholar -
Yamaguchi,Y., Cavallero, S., Patterson,M., Shen, H., Xu,J., Kumar, S.,R., Sucov, H.,M.(2015) Adipogenesis and epicardial adipose tissue: a novel fate of the epicardium induced by mesenchymal transformation and PPARγ (Peroxisome proliferator- activated receptor gamma) activation, Proceedings of the Natlonal Academy of Sciences, 112, 2070–2075
View at Publisher | View at Google Scholar -
Frescura. C., Basso, C., Thiene. G., Corrado. D., Pennelli, T., Angelini, A., et al (1998). Anomalous origin of coronary arteries and risk of sudden death: a study based on an autopsy population of congenital heart disease. Human Pathology. 29, 689–695.
View at Publisher | View at Google Scholar -
Thiene, G., Rizzo, S., Frescura, C., Basso, C.. (2020) Chapter 21: Specific cardiovascular diseases and competitive sports participation: coronary anomalies and myocardial bridging at risk of sudden death. In: Pressler A, Niebauer J, editors. Textbook of Sports and Exercise Cardiology. Cham: Switzerland Springer p. 403–421.
View at Publisher | View at Google Scholar -
Angelini, P., Trivellato, M., Donis, J., Leachman. R.,D..(1983) Myocardial bridge: a review. Progress in Cardiovascukar Diseases, 26, 75–88.
View at Publisher | View at Google Scholar -
Mohlenkamp,S.,Hort, W, Ge, J.,Erbel, R., (2002) Update on myocardial bridging, Circulation,106, 2616- 2622.
View at Publisher | View at Google Scholar -
Virmani, R., Chun, P.,K.,.C., Goldstein, R.,E., Robinowitz, M., McAllister, H.,A.(1986)Acute takeoffs of the coronary arteries along the aortic wall and congenital coronaryostial valve-like ridges: association with sudden death..Journal of American College of Cardiology, 3, 766-771
View at Publisher | View at Google Scholar -
Bloomfield, P., Erhlichm C,, Folland, A.,D., Bianco, J., Tow, D.,E., Parisi, A.,F.(1983) A surgically correctable cause of angina pectoris..American Journal of Cardiology, 51, 1235-1237
View at Publisher | View at Google Scholar -
Frommelt, P.,C., Frommelt, M.,A., Tweddell, J.,S., Jaquiss, R.,D .(2003) Prospective echocardiographic diagnosis and surgical repair of anomalous origin of a coronary artery from the opposite sinus with an interarterial course..,Journal of American College of Cardiology, 42, 148-154.
View at Publisher | View at Google Scholar -
Basso, C., Corrado, D., Thiene, G.,(2001) Congenital coronary anomalies as an important cause of sudden death in the young..Cardiology in Review, 9, 312-317
View at Publisher | View at Google Scholar -
Angelini, P., Velasco, J.,A., Ott, D., Khoshnevis, G.,R. (2003)..Anomalous coronary artery arising from the opposite sinus: descriptive features and pathophysiologic mechanisms, as documented by intravascular ultrasonography..
View at Publisher | View at Google Scholar -
Journal of Invasive Cardiology, 15, 507-514.
View at Publisher | View at Google Scholar -
Duncker, D.,J., et al (2015) Regulation of coronary blood flow in health and ischemic heart disease. Progress in Cardiovascular Diseases, 57, 409–422.
View at Publisher | View at Google Scholar -
Furchgott, R.,F., Zawadzki, J.,V (1980)The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 288, 373–376.
View at Publisher | View at Google Scholar -
Pries, A.,R., et al (2015) Coronary vascular regulation, remodelling, and collateralization: mechanisms and clinical implications on behalf of the working group on coronary pathophysiology and microcirculation. European Heart Journal,. 36, 3134–3146.
View at Publisher | View at Google Scholar -
Kaski, J.,C., et al (2018) Reappraisal of ischemic heart disease. Circulation, 138, 1463–1480.
View at Publisher | View at Google Scholar -
Ong P, et al (2012) High prevalence of a pathological response to acetylcholine testing in patients with stable angina pectoris and unobstructed coronary arteries: the ACOVA study. Journal of American College of Cardiology, 59, 655–662.
View at Publisher | View at Google Scholar -
Camici, P.,G., Crea, F. (2007) Coronary microvascular dysfunction,New England Journal of Medicine, 356, 830‐840.
View at Publisher | View at Google Scholar -
Bradley, C., Berry, C. (2022) Definition and epidemiology of coronary microvascular disease. Journal of Nuclear Cardiology. 29, 1763–1775..
View at Publisher | View at Google Scholar -
Gulati, M., Shaw, L.,J., Bairey Merz, C.,N (2012) Myocardial ischemia in women: lessons from the NHLBI WISE study. Clinical Cardiology,.35, 141–148.
View at Publisher | View at Google Scholar -
Cosin-Sales, J., et al (2003) C-reactive protein, clinical presentation, and ischemic activity in patients with chest pain and normal coronary angiograms. Journal of American College of Cardiology, 41, 1468–1474.
View at Publisher | View at Google Scholar -
Ong, P., et al (2012) Increased coronary vasoconstrictor response to acetylcholine in women with chest pain and normal coronary arteriograms (cardiac syndrome X). Clinical Research in Cardiology. 101, 673–681.
View at Publisher | View at Google Scholar -
Matsuda, Y., et al (1983) Coronary arteriography and left ventriculography during spontaneous and exercise-induced ST segment elevation in patients with variant angina, American Heart Journal., 106, 509–515.
View at Publisher | View at Google Scholar -
Minoda, K., et al (1994) Comparison of the distribution of myocardial blood flow between exercise-induced and hyperventilation-induced attacks of coronary spasm: a study with thallium-201 myocardial scintigraphy. American Heart Journal, 127, 1474–1480.
View at Publisher | View at Google Scholar -
Sara, J.,D., et al (2015) Prevalence of coronary microvascular dysfunction among patients with chest pain and nonobstructive coronary artery disease. JACC Cardiovascular Interventions, 8, 1445–1453.
View at Publisher | View at Google Scholar -
Sueda, S, et al (2016). Gender differences in sensitivity of acetylcholine and ergonovine to coronary spasm provocation test. Heart Vessels, 31, 322–329.
View at Publisher | View at Google Scholar -
Everaars, H., et a (2018)l Doppler flow velocity thermodilution to assess coronary flow reserve: a head-to-head comparison with [(15)O]H2O PET. JACC Cardiovascular Interventions, 11, 2044–2054.
View at Publisher | View at Google Scholar -
Taqueti, V.,R., Di Carli M.,F. (2016) Clinical significance of noninvasive coronary flow reserve assessment in patients with ischemic heart disease. Current Opinion in Cardiology. 31, 662–669.
View at Publisher | View at Google Scholar -
Ford, T.,J., Berry, C, (2019) How to diagnose and manage angina without obstructive coronary artery disease: lessons from the british heart foundation CorMicA trial. Interventional Cardiology., 14, 76–82.
View at Publisher | View at Google Scholar -
Williams, R.,P., et al (2018)Doppler versus thermodilution-derived coronary microvascular resistance to predict coronary microvascular dysfunction in patients with acute myocardial infarction or stable angina pectoris. American Journal of Cardiology, 121, 1–8.
View at Publisher | View at Google Scholar -
Rahman, H., et al (2020) Physiological stratification of patients with angina due to coronary microvascular dysfunction. Journal of American College of Cardiology, 75, 2538–2549.
View at Publisher | View at Google Scholar -
Knuuti, J., et al (2020). ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal, 41, 407–477.
View at Publisher | View at Google Scholar -
Thomson, L.,E., et al (2015). Cardiac magnetic resonance myocardial perfusion reserve index is reduced in women with coronary microvascular dysfunction. A national heart, lung, and blood institute-sponsored study from the women's ischemia syndrome evaluation. Circulation: Cardiovascular Imaging. 8, 2481.
View at Publisher | View at Google Scholar -
Taqueti ,V.,R., Di Carli, M.,F.(2016) Clinical significance of noninvasive coronary flow reserve assessment in patients with ischemic heart disease. Current Opinion in Cardiology, 31, 662–669.
View at Publisher | View at Google Scholar -
Kaufmann, P.,A., et al (1999) Assessment of the reproducibility of baseline hyperemic myocardial blood flow measurements with 15O-labeled water PET. Journal of Nuclear Medicine., 40, 1848–1856.
View at Publisher | View at Google Scholar -
Nagamachi, S., et al (1996) Reproducibility of measurements of regional resting hyperemic myocardial blood flow assessed with PET. Journal of Nuclear Medicine., 37, 1626–1631.
View at Publisher | View at Google Scholar -
Everaars, H., et al (2018) Doppler flow velocity thermodilution to assess coronary flow reserve: a head-to-head comparison with [(15)O]H2O PET. JACC Cardiovascular Interventions, 11, 2044–2054.
View at Publisher | View at Google Scholar -
Bravo, P.,E., Di Carli, M.,F., Dorbala, A (2017) Role of PET to evaluate coronary microvascular dysfunction in non-ischemic cardiomyopathies. Heart failure reviews, 22,455–464.
View at Publisher | View at Google Scholar -
Kuruvilla, S., Kramer, C.,M (2013) Coronary microvascular dysfunction in women: an overview of diagnostic strategies. Expert Review of Cardiovascular Therapy. 11, 1515–1525.
View at Publisher | View at Google Scholar -
Maddahi, J., Packard, R.,R.,S. (2014) Cardiac PET perfusion tracers: current status and future directions. Seminars in Nuclear Medicine., 44, 333–343.
View at Publisher | View at Google Scholar