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Research Article | DOI: https://doi.org/CCSRR-25-RA-30

Association of H. Pylori Infection with Changes in Molecular Markers of Inflammation in Patients with Incident Hypertension Attending Federal University Teaching Hospital Owerri, imo state

Nwachukwu Uchenna Christiantus 1, Nwadike Constance N 1, Johnkennedy Nnodim 1*, Mgbeosuru Benson Chikodi 1, Arinzechi Ekpereamaka Ginika 1, Gilbert Ifechukwu Precious 1, Oko Oluebube Miracle 1, Mbarah Ifunanya Emmanuella 1, Amaobi Rosecollet N 1, Imakwu Icha Innocent 2

1 Department of Medical Laboratory Science, Imo State University, Owerri Nigeria

2 Department of Pharmacology and Therapeutics. Institution: David Umahi Federal University of Health sciences, Uburu Ebonyi  state

*Corresponding Author: Johnkennedy Nnodim, Department of Medical Laboratory Science, Imo State University, Owerri Nigeria

Citation: Nwachukwu Uchenna Christiantus, Nwadike Constance N, Johnkennedy Nnodim, Mgbeosuru Benson Chikodi, Arinzechi Ekpereamaka Ginika et al (2025). Association of H. Pylori Infection with Changes in Molecular Markers of Inflammation in Patients with Incident Hypertension Attending Federal University Teaching Hospital Owerri, imo state, J Clinical Case Studies and Review Reports. 2(5) 30, DOI: CCSRR-25-RA-30

Copyright: Johnkennedy Nnodim, et al © (2025). This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Received: 02 June 2025 | Accepted: 09 June 2025 | Published: 20 June 2025

Keywords: pylori infection; inflammation; hypertension owerri

Abstract

Helicobacter pylori (H. pylori) infection and hypertension are associated with chronic inflammation. This study investigates the association of molecular markers of inflammation in H. pylori-infected patients with incident hypertension attending selected hospitals in Imo State, Nigeria. A total of 100 adult participants (aged 20-60 years) were recruited and categorized into four groups (n 25 each): Group 1 (Control): Normotensive, H. pylori-negative. Group 2: Hypertensive, H. pylori-positive. Group 3: Hypertensive, H. pylori-negative. Group 4: Normotensive, H. pylori-positive. Parameters assessed included: C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), Immunoglobulin M(IgM), Immunoglobulin G(IgG). Data were analyzed using one-way ANOVA (p<0.05). Group 2 (hypertensive, H. pylori+) consistently showed the most elevated values across inflammatory and lipid markers but a decreased patelet values. Key findings (mean ± SD) include:. CRP (mg/L): G1: 2.10 ± 0.51; G2: 6.78 ± 0.87; G3: 5.96 ± 0.79; G4: 4.84 ± 0.69. IL-6 (pg/mL): G1: 3.44±0.62; G2: 8.76 ± 0.91; G3: 7.10 ±0.80; G4: 6.34±0.74. TNF-a (pg/mL): G1: 4.26 ± 0.58; G2: 9.12 ± 1.04; G3: 8.02 ± 0.88; G4: 6.98 ±0.81. IgM(mg/dl): G1:93.08±17.59; G2:134.44±13.48;G3:97.80±16.76;G4:118.20±16.83. IgG(mg/dl):G1:1174.84±153.28;G2:1705.40±143.21;G3:1275.36±161.83;G4:1649.68±110.16.Statistical analysis revealed significant differences across all groups in all parameter (p<0.05), with Group 2 showing the most pronounced elevations in inflammatory. The combination of H. pylori infection and hypertension is associated with significant upregulation of molecular markers of inflammation. Group 2 displayed a synergistic exacerbation of systemic inflammation, suggesting an increased risk of cardiovascular events.

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